Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Choong Yeon Kim, Min Jeong Ku, Raza Qazi, Hong Jae Nam, Jong Woo Park, Kum Seok Nam, Shane Oh, Inho Kang, Jae-Hyung Jang, Wha Young Kim, Jeong-Hoon Kim () and Jae-Woong Jeong ()
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Choong Yeon Kim: Korea Advanced Institute of Science and Technology
Min Jeong Ku: Yonsei University College of Medicine
Raza Qazi: Korea Advanced Institute of Science and Technology
Hong Jae Nam: Korea Advanced Institute of Science and Technology
Jong Woo Park: Yonsei University College of Medicine
Kum Seok Nam: Korea Advanced Institute of Science and Technology
Shane Oh: Korea Advanced Institute of Science and Technology
Inho Kang: Korea Advanced Institute of Science and Technology
Jae-Hyung Jang: Yonsei University
Wha Young Kim: Yonsei University College of Medicine
Jeong-Hoon Kim: Yonsei University College of Medicine
Jae-Woong Jeong: Korea Advanced Institute of Science and Technology

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.

Date: 2021
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DOI: 10.1038/s41467-020-20803-y

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