Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy

Farrokh Dehdashti (), Ningying Wu, Cynthia X. Ma, Michael J. Naughton, John A. Katzenellenbogen and Barry A. Siegel
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Farrokh Dehdashti: Washington University School of Medicine
Ningying Wu: Washington University School of Medicine
Cynthia X. Ma: Washington University School of Medicine
Michael J. Naughton: Saint Francis Healthcare, Cape Medical Oncology
John A. Katzenellenbogen: University of Illinois
Barry A. Siegel: Washington University School of Medicine

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor uptake of the progestin analog, 21-[18F]fluorofuranylnorprogesterone (FFNP), before and after a one-day estradiol challenge. In 43 postmenopausal women with advanced ER+ breast cancer, we show a post-challenge increase in tumor FFNP uptake only in 28 subjects with clinical benefit from ET (responders), but not in 15 without clinical benefit (nonresponders) (p

Date: 2021
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DOI: 10.1038/s41467-020-20814-9

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