GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Daniel Eriksson, Ellen Christine Røyrvik, Maribel Aranda-Guillén, Amund Holte Berger, Nils Landegren, Haydee Artaza, Åsa Hallgren, Marianne Aardal Grytaas, Sara Ström, Eirik Bratland, Ileana Ruxandra Botusan, Bergithe Eikeland Oftedal, Lars Breivik, Marc Vaudel, Øyvind Helgeland, Alberto Falorni, Anders Palmstrøm Jørgensen, Anna-Lena Hulting, Johan Svartberg, Olov Ekwall, Kristian Johan Fougner, Jeanette Wahlberg, Bjørn Gunnar Nedrebø, Per Dahlqvist, Per Morten Knappskog, Anette Susanne Bøe Wolff, Sophie Bensing, Stefan Johansson, Olle Kämpe () and Eystein Sverre Husebye ()
Additional contact information
Daniel Eriksson: Karolinska Institutet
Ellen Christine Røyrvik: University of Bergen
Maribel Aranda-Guillén: Karolinska Institutet
Amund Holte Berger: University of Bergen
Nils Landegren: Karolinska Institutet
Haydee Artaza: University of Bergen
Åsa Hallgren: Karolinska Institutet
Marianne Aardal Grytaas: University of Bergen
Sara Ström: Karolinska University Hospital
Eirik Bratland: University of Bergen
Ileana Ruxandra Botusan: Karolinska University Hospital
Bergithe Eikeland Oftedal: University of Bergen
Lars Breivik: University of Bergen
Marc Vaudel: University of Bergen
Øyvind Helgeland: University of Bergen
Alberto Falorni: University of Perugia
Anders Palmstrøm Jørgensen: Oslo University Hospital
Anna-Lena Hulting: Karolinska Institutet
Johan Svartberg: UiT The Arctic University of Norway
Olov Ekwall: University of Gothenburg
Kristian Johan Fougner: St. Olavs Hospital
Jeanette Wahlberg: Linköping University
Bjørn Gunnar Nedrebø: University of Bergen
Per Dahlqvist: Umeå University
Per Morten Knappskog: University of Bergen
Anette Susanne Bøe Wolff: University of Bergen
Sophie Bensing: Karolinska University Hospital
Stefan Johansson: University of Bergen
Olle Kämpe: Karolinska Institutet
Eystein Sverre Husebye: Karolinska Institutet

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P

Date: 2021
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DOI: 10.1038/s41467-021-21015-8

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