Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex

XiaoTing Zheng, Kirstie J. Salinas, Dario X. Figueroa Velez, Taylor Nakayama, Xiaoxiao Lin, Dhruba Banerjee, Xiangmin Xu and Sunil P. Gandhi ()
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XiaoTing Zheng: University of California, Irvine
Kirstie J. Salinas: University of California, Irvine
Dario X. Figueroa Velez: University of California, Irvine
Taylor Nakayama: University of California, Irvine
Xiaoxiao Lin: University of California, Irvine
Dhruba Banerjee: University of California, Irvine
Xiangmin Xu: University of California, Irvine
Sunil P. Gandhi: University of California, Irvine

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract The adult brain lacks sensitivity to changes in the sensory environment found in the juvenile brain. The transplantation of embryonic interneurons has been shown to restore juvenile plasticity to the adult host visual cortex. It is unclear whether transplanted interneurons directly mediate the renewed cortical plasticity or whether these cells act indirectly by modifying the host interneuron circuitry. Here we find that the transplant-induced reorganization of mouse host circuits is specifically mediated by Neuregulin (NRG1)/ErbB4 signaling in host parvalbumin (PV) interneurons. Brief visual deprivation reduces the visual activity of host PV interneurons but has negligible effects on the responses of transplanted PV interneurons. Exogenous NRG1 both prevents the deprivation-induced reduction in the visual responses of host PV interneurons and blocks the transplant-induced reorganization of the host circuit. While deletion of ErbB4 receptors from host PV interneurons blocks cortical plasticity in the transplant recipients, deletion of the receptors from the donor PV interneurons does not. Altogether, our results indicate that transplanted embryonic interneurons reactivate cortical plasticity by rejuvenating the function of host PV interneurons.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21097-4

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DOI: 10.1038/s41467-021-21097-4

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