Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

Pierre-Eric Lutz, Marc-Aurèle Chay, Alain Pacis, Gary G. Chen, Zahia Aouabed, Elisabetta Maffioletti, Jean-François Théroux, Jean-Christophe Grenier, Jennie Yang, Maria Aguirre, Carl Ernst, Adriana Redensek, Léon C. Kempen, Ipek Yalcin, Tony Kwan, Naguib Mechawar, Tomi Pastinen and Gustavo Turecki ()
Additional contact information
Pierre-Eric Lutz: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Marc-Aurèle Chay: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Alain Pacis: CHU Sainte-Justine Research Center
Gary G. Chen: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Zahia Aouabed: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Elisabetta Maffioletti: Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
Jean-François Théroux: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Jean-Christophe Grenier: CHU Sainte-Justine Research Center
Jennie Yang: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Maria Aguirre: McGill University
Carl Ernst: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Adriana Redensek: McGill University
Léon C. Kempen: McGill University
Ipek Yalcin: Centre National de la Recherche Scientifique, Institut des Neurosciences Cellulaires et Intégratives, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg
Tony Kwan: McGill University
Naguib Mechawar: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University
Tomi Pastinen: McGill University
Gustavo Turecki: McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University

Nature Communications, 2021, vol. 12, issue 1, 1-16

Abstract: Abstract Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifetime risk by epigenetically regulating the genome. Here, focusing on the lateral amygdala, a major brain site for emotional homeostasis, we describe molecular cross-talk among multiple mechanisms of genomic regulation, including 6 histone marks and DNA methylation, and the transcriptome, in subjects with a history of ELA and controls. In the healthy brain tissue, we first uncover interactions between different histone marks and non-CG methylation in the CAC context. Additionally, we find that ELA associates with methylomic changes that are as frequent in the CAC as in the canonical CG context, while these two forms of plasticity occur in sharply distinct genomic regions, features, and chromatin states. Combining these multiple data indicates that immune-related and small GTPase signaling pathways are most consistently impaired in the amygdala of ELA individuals. Overall, this work provides insights into genomic brain regulation as a function of early-life experience.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-21365-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21365-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-21365-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().