Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition

Bingfang Zhang, Lei Wang, Aisheng Zhan, Min Wang, Lanxiang Tian (), Weixiang Guo () and Yongxin Pan
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Bingfang Zhang: Chinese Academy of Sciences
Lei Wang: University of Chinese Academy of Sciences
Aisheng Zhan: Chinese Academy of Sciences
Min Wang: Chinese Academy of Sciences
Lanxiang Tian: Chinese Academy of Sciences
Weixiang Guo: University of Chinese Academy of Sciences
Yongxin Pan: Chinese Academy of Sciences

Nature Communications, 2021, vol. 12, issue 1, 1-17

Abstract: Abstract Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect adult hippocampal neurogenesis and hippocampus-dependent cognitions is still an enigma. Here, we showed that male C57BL/6 J mice exposed to HMF by means of near elimination of the geomagnetic field (GMF) exhibit significant impairments of adult hippocampal neurogenesis and hippocampus-dependent learning, which is strongly correlated with a reduction in the content of reactive oxygen species (ROS). However, these deficits seen in HMF-exposed mice could be rescued either by elevating ROS levels through pharmacological inhibition of ROS removal or by returning them back to GMF. Therefore, our results suggest that GMF plays an important role in adult hippocampal neurogenesis through maintaining appropriate endogenous ROS levels.

Date: 2021
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DOI: 10.1038/s41467-021-21468-x

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