Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

Eleanor Sinclair, Drupad K. Trivedi, Depanjan Sarkar, Caitlin Walton-Doyle, Joy Milne, Tilo Kunath, Anouk M. Rijs, Rob M. A. Bie, Royston Goodacre, Monty Silverdale and Perdita Barran ()
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Eleanor Sinclair: The University of Manchester
Drupad K. Trivedi: The University of Manchester
Depanjan Sarkar: The University of Manchester
Caitlin Walton-Doyle: The University of Manchester
Joy Milne: The University of Manchester
Tilo Kunath: The University of Edinburgh
Anouk M. Rijs: Vrije Universiteit Amsterdam
Rob M. A. Bie: University of Amsterdam
Royston Goodacre: University of Liverpool
Monty Silverdale: University of Manchester
Perdita Barran: The University of Manchester

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.

Date: 2021
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DOI: 10.1038/s41467-021-21669-4

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