Hyocholic acid species as novel biomarkers for metabolic disorders

Xiaojiao Zheng, Tianlu Chen, Aihua Zhao, Zhangchi Ning, Junliang Kuang, Shouli Wang, Yijun You, Yuqian Bao, Xiaojing Ma, Haoyong Yu, Jian Zhou, Miao Jiang, Mengci Li, Jieyi Wang, Xiaohui Ma, Shuiping Zhou, Yitao Li, Kun Ge, Cynthia Rajani, Guoxiang Xie, Cheng Hu, Yike Guo, Aiping Lu (), Weiping Jia () and Wei Jia ()
Additional contact information
Xiaojiao Zheng: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Tianlu Chen: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Aihua Zhao: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Zhangchi Ning: Hong Kong Baptist University
Junliang Kuang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Shouli Wang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yijun You: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Yuqian Bao: Shanghai Diabetes Institute
Xiaojing Ma: Shanghai Diabetes Institute
Haoyong Yu: Shanghai Diabetes Institute
Jian Zhou: Shanghai Diabetes Institute
Miao Jiang: China Academy of Chinese Medical Sciences
Mengci Li: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Jieyi Wang: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Xiaohui Ma: Tasly Pharmaceutical Co. Ltd
Shuiping Zhou: Tasly Pharmaceutical Co. Ltd
Yitao Li: Hong Kong Baptist University
Kun Ge: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Cynthia Rajani: University of Hawaii Cancer Center
Guoxiang Xie: University of Hawaii Cancer Center
Cheng Hu: Shanghai Diabetes Institute
Yike Guo: Hong Kong Baptist University
Aiping Lu: Hong Kong Baptist University
Weiping Jia: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Wei Jia: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict the development of metabolic disorders. We find in the first cohort (n = 1107) that both obesity and diabetes are associated with lower serum concentrations of HCA species. A separate cohort study (n = 91) validates this finding and further reveals that individuals with pre-diabetes are associated with lower levels of HCA species in feces. Serum HCA levels increase in the patients after gastric bypass surgery (n = 38) and can predict the remission of diabetes two years after surgery. The results are replicated in two independent, prospective cohorts (n = 132 and n = 207), where serum HCA species are found to be strong predictors for metabolic disorders in 5 and 10 years, respectively. These findings underscore the association of HCA species with diabetes, and demonstrate the feasibility of using HCA profiles to assess the future risk of developing metabolic abnormalities.

Date: 2021
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DOI: 10.1038/s41467-021-21744-w

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