Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

Purui Zheng, Pan Zhou, Dong Wang, Wenhao Xu, Hepan Wang and Tao Xu ()
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Purui Zheng: Tongji University
Pan Zhou: Tongji University
Dong Wang: Tongji University
Wenhao Xu: Tongji University
Hepan Wang: Tongji University
Tao Xu: Tongji University

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities.

Date: 2021
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DOI: 10.1038/s41467-021-21947-1

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