Importance of circadian timing for aging and longevity

Victoria A. Acosta-Rodríguez, Filipa Rijo-Ferreira, Carla B. Green and Joseph S. Takahashi ()
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Victoria A. Acosta-Rodríguez: University of Texas Southwestern Medical Center
Filipa Rijo-Ferreira: University of Texas Southwestern Medical Center
Carla B. Green: University of Texas Southwestern Medical Center
Joseph S. Takahashi: University of Texas Southwestern Medical Center

Nature Communications, 2021, vol. 12, issue 1, 1-12

Abstract: Abstract Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well as by adjusting nutritional composition. Because these factors are often combined during DR, it is unclear which are necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of which change expression throughout the day, suggesting that the timing of drug administration is critical. Here, we discuss how dietary and pharmacological interventions promote a healthy lifespan by influencing energy intake and circadian rhythms.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22922-6

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DOI: 10.1038/s41467-021-22922-6

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