Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

Shuyi Wu, Jianmeng Xu, Leiyan Zou, Shulu Luo, Run Yao, Bingna Zheng, Guobin Liang, Dingcai Wu () and Yan Li ()
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Shuyi Wu: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Jianmeng Xu: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Leiyan Zou: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Shulu Luo: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Run Yao: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Bingna Zheng: Sun Yat-sen University
Guobin Liang: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University
Dingcai Wu: Sun Yat-sen University
Yan Li: Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection.

Date: 2021
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DOI: 10.1038/s41467-021-23069-0

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