Porous functionalized polymers enable generating and transporting hyperpolarized mixtures of metabolites

Théo El Daraï, Samuel F. Cousin (), Quentin Stern, Morgan Ceillier, James Kempf, Dmitry Eshchenko, Roberto Melzi, Marc Schnell, Laurent Gremillard, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Olivier Cala, Damien Montarnal () and Sami Jannin
Additional contact information
Théo El Daraï: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Samuel F. Cousin: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Quentin Stern: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Morgan Ceillier: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
James Kempf: Bruker Biospin
Dmitry Eshchenko: Bruker Biospin
Roberto Melzi: Bruker Italia Srl
Marc Schnell: Bruker Biospin
Laurent Gremillard: Université de Lyon, INSA Lyon, MATEIS UMR CNRS 5510, Bât. Blaise Pascal
Aurélien Bornet: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Jonas Milani: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Basile Vuichoud: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Olivier Cala: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon
Damien Montarnal: Université de Lyon, CPE Lyon, CNRS, Catalyse, Chimie, Polymères et Procédés, UMR 5265
Sami Jannin: Université de Lyon, Centre de RMN à Très Hauts Champs de Lyon, UMR5082 - CNRS/UCBL/ENS de Lyon

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Hyperpolarization by dissolution dynamic nuclear polarization (dDNP) has enabled promising applications in spectroscopy and imaging, but remains poorly widespread due to experimental complexity. Broad democratization of dDNP could be realized by remote preparation and distribution of hyperpolarized samples from dedicated facilities. Here we show the synthesis of hyperpolarizing polymers (HYPOPs) that can generate radical- and contaminant-free hyperpolarized samples within minutes with lifetimes exceeding hours in the solid state. HYPOPs feature tunable macroporous porosity, with porous volumes up to 80% and concentration of nitroxide radicals grafted in the bulk matrix up to 285 μmol g−1. Analytes can be efficiently impregnated as aqueous/alcoholic solutions and hyperpolarized up to P(13C) = 25% within 8 min, through the combination of 1H spin diffusion and 1H → 13C cross polarization. Solutions of 13C-analytes of biological interest hyperpolarized in HYPOPs display a very long solid-state 13C relaxation times of 5.7 h at 3.8 K, thus prefiguring transportation over long distances.

Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-24279-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24279-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-24279-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().