Towards a synthetic cell cycle

Lorenzo Olivi, Mareike Berger, Ramon N. P. Creyghton, Nicola De Franceschi, Cees Dekker, Bela M. Mulder, Nico J. Claassens, Pieter Rein ten Wolde () and John van der Oost ()
Additional contact information
Lorenzo Olivi: Wageningen University
Mareike Berger: Institute AMOLF
Ramon N. P. Creyghton: Institute AMOLF
Nicola De Franceschi: Delft University of Technology
Cees Dekker: Delft University of Technology
Bela M. Mulder: Institute AMOLF
Nico J. Claassens: Wageningen University
Pieter Rein ten Wolde: Institute AMOLF
John van der Oost: Wageningen University

Nature Communications, 2021, vol. 12, issue 1, 1-11

Abstract: Abstract Recent developments in synthetic biology may bring the bottom-up generation of a synthetic cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which DNA replication and segregation as well as cell growth and division are well integrated. Here, we describe different approaches to recreate these processes in a synthetic cell, based on natural systems and/or synthetic alternatives. Although some individual machineries have recently been established, their integration and control in a synthetic cell cycle remain to be addressed. In this Perspective, we discuss potential paths towards an integrated synthetic cell cycle.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24772-8

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DOI: 10.1038/s41467-021-24772-8

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