Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

Burair A. Alsaihati, Kun-Lin Ho, Joshua Watson, Yuan Feng, Tianfang Wang, Kevin K. Dobbin and Shaying Zhao ()
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Burair A. Alsaihati: University of Georgia
Kun-Lin Ho: University of Georgia
Joshua Watson: University of Georgia
Yuan Feng: University of Georgia
Tianfang Wang: University of Georgia
Kevin K. Dobbin: University of Georgia
Shaying Zhao: University of Georgia

Nature Communications, 2021, vol. 12, issue 1, 1-13

Abstract: Abstract Spontaneous canine cancers are valuable but relatively understudied and underutilized models. To enhance their usage, we reanalyze whole exome and genome sequencing data published for 684 cases of >7 common tumor types and >35 breeds, with rigorous quality control and breed validation. Our results indicate that canine tumor alteration landscape is tumor type-dependent, but likely breed-independent. Each tumor type harbors major pathway alterations also found in its human counterpart (e.g., PI3K in mammary tumor and p53 in osteosarcoma). Mammary tumor and glioma have lower tumor mutational burden (TMB) (median

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24836-9

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DOI: 10.1038/s41467-021-24836-9

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