Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling

Maximilian Stangier, Antonis M. Messinis, João C. A. Oliveira, Hao Yu and Lutz Ackermann ()
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Maximilian Stangier: Georg-August-Universität Göttingen
Antonis M. Messinis: Georg-August-Universität Göttingen
João C. A. Oliveira: Georg-August-Universität Göttingen
Hao Yu: Georg-August-Universität Göttingen
Lutz Ackermann: Georg-August-Universität Göttingen

Nature Communications, 2021, vol. 12, issue 1, 1-8

Abstract: Abstract Chromones represent a privileged scaffold in medicinal chemistry and are an omnipresent structural motif in natural products. Chemically encoded non-natural peptidomimetics feature improved stability towards enzymatic degradation, cell permeability and binding affinity, translating into a considerable impact on pharmaceutical industry. Herein, a strategy for the sustainable assembly of chromones via electro-formyl C–H activation is presented. The rational design of the rhodaelectro-catalysis is guided by detailed mechanistic insights and provides versatile access to tyrosine-based fluorogenic peptidomimetics.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25005-8

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DOI: 10.1038/s41467-021-25005-8

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