A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King and Hermann Brenner ()
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Janhavi R. Raut: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
Ben Schöttker: German Cancer Research Center (DKFZ)
Bernd Holleczek: Saarland Cancer Registry
Feng Guo: University of Heidelberg
Megha Bhardwaj: German Cancer Research Center (DKFZ)
Kaya Miah: German Cancer Research Center (DKFZ)
Petra Schrotz-King: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)
Hermann Brenner: German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT)

Nature Communications, 2021, vol. 12, issue 1, 1-9

Abstract: Abstract Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50–75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95% CI) is 0.557 (0.498–0.616) for the ERS and 0.622 (0.564–0.681) for the PRS.

Date: 2021
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DOI: 10.1038/s41467-021-25067-8

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