Microglia have a grip on brain microvasculature

Kassandra Kisler, Angeliki Maria Nikolakopoulou and Berislav V. Zlokovic ()
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Kassandra Kisler: Keck School of Medicine of the University of Southern California
Angeliki Maria Nikolakopoulou: Keck School of Medicine of the University of Southern California
Berislav V. Zlokovic: Keck School of Medicine of the University of Southern California

Nature Communications, 2021, vol. 12, issue 1, 1-3

Abstract: Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.

Date: 2021
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DOI: 10.1038/s41467-021-25595-3

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