TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang (), Yanfeng Wu () and Huiyong Shen ()
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Zhongyu Xie: Sun Yat-sen University
Wenhui Yu: Sun Yat-sen University
Guan Zheng: Sun Yat-sen University
Jinteng Li: Sun Yat-sen University
Shuizhong Cen: Sun Yat-sen University
Guiwen Ye: Sun Yat-sen University
Zhaofeng Li: Sun Yat-sen University
Wenjie Liu: Sun Yat-sen University
Ming Li: Sun Yat-sen University
Jiajie Lin: Sun Yat-sen University
Zepeng Su: Sun Yat-sen University
Yunshu Che: Sun Yat-sen University
Feng Ye: Sun Yat-sen University
Peng Wang: Sun Yat-sen University
Yanfeng Wu: Sun Yat-sen University
Huiyong Shen: Sun Yat-sen University

Nature Communications, 2021, vol. 12, issue 1, 1-14

Abstract: Abstract Ankylosing spondylitis (AS) is a type of rheumatic disease characterized by chronic inflammation and pathological osteogenesis in the entheses. Previously, we demonstrated that enhanced osteogenic differentiation of MSC from AS patients (AS-MSC) resulted in pathological osteogenesis, and that during the enhanced osteogenic differentiation course, AS-MSC induced TNF-α-mediated local inflammation. However, whether TNF-α in turn affects AS-MSC remains unknown. Herein, we further demonstrate that a high-concentration TNF-α treatment triggers enhanced directional migration of AS-MSC in vitro and in vivo, which enforces AS pathogenesis. Mechanistically, TNF-α leads to increased expression of ELMO1 in AS-MSC, which is mediated by a METTL14 dependent m6A modification in ELMO1 3′UTR. Higher ELMO1 expression of AS-MSC is found in vivo in AS patients, and inhibiting ELMO1 in SKG mice produces therapeutic effects in this spondyloarthritis model. This study may provide insight into not only the pathogenesis but also clinical therapy for AS.

Date: 2021
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DOI: 10.1038/s41467-021-25710-4

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