Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis

Saurabh J. Pradhan, Puli Chandramouli Reddy, Michael Smutny, Ankita Sharma, Keisuke Sako, Meghana S. Oak, Rini Shah, Mrinmoy Pal, Ojas Deshpande, Greg Dsilva, Yin Tang, Rakesh Mishra, Girish Deshpande, Antonio J. Giraldez, Mahendra Sonawane, Carl-Philipp Heisenberg () and Sanjeev Galande ()
Additional contact information
Saurabh J. Pradhan: Indian Institute of Science Education and Research
Puli Chandramouli Reddy: Indian Institute of Science Education and Research
Michael Smutny: Institute of Science and Technology Austria
Ankita Sharma: Indian Institute of Science Education and Research
Keisuke Sako: Institute of Science and Technology Austria
Meghana S. Oak: Indian Institute of Science Education and Research
Rini Shah: Indian Institute of Science Education and Research
Mrinmoy Pal: Indian Institute of Science Education and Research
Ojas Deshpande: Indian Institute of Science Education and Research
Greg Dsilva: Indian Institute of Science Education and Research
Yin Tang: Yale University School of Medicine
Rakesh Mishra: Centre for Cellular and Molecular Biology
Girish Deshpande: Princeton University
Antonio J. Giraldez: Yale University School of Medicine
Mahendra Sonawane: Tata Institute of Fundamental Research
Carl-Philipp Heisenberg: Institute of Science and Technology Austria
Sanjeev Galande: Indian Institute of Science Education and Research

Nature Communications, 2021, vol. 12, issue 1, 1-19

Abstract: Abstract Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent upon dynamic chromatin architecture sculpted by conserved DNA-binding proteins. However, the direct mechanistic link between the onset of ZGA and the tissue-specific transcription remains unclear. Here, we have addressed the involvement of chromatin organizer Satb2 in orchestrating both processes during zebrafish embryogenesis. Integrative analysis of transcriptome, genome-wide occupancy and chromatin accessibility reveals contrasting molecular activities of maternally deposited and zygotically synthesized Satb2. Maternal Satb2 prevents premature transcription of zygotic genes by influencing the interplay between the pluripotency factors. By contrast, zygotic Satb2 activates transcription of the same group of genes during neural crest development and organogenesis. Thus, our comparative analysis of maternal versus zygotic function of Satb2 underscores how these antithetical activities are temporally coordinated and functionally implemented highlighting the evolutionary implications of the biphasic and bimodal regulation of landmark developmental transitions by a single determinant.

Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-021-26234-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26234-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-021-26234-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().