Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Adrienne Tin (), Pascal Schlosser, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Victoria L. Halperin Kuhns, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Graciela E. Delgado, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, James S. Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C. Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M. Lloyd-Jones, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Joyce B. J. Meurs, Jana V. Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M. Woodward, Katalin Susztak, Alexander Teumer and Anna Köttgen ()
Additional contact information
Adrienne Tin: University of Mississippi Medical Center
Pascal Schlosser: Johns Hopkins Bloomberg School of Public Health
Pamela R. Matias-Garcia: German Research Center for Environmental Health
Chris H. L. Thio: University of Groningen, University Medical Center Groningen
Roby Joehanes: Framingham Heart Study
Hongbo Liu: University of Pennsylvania Perelman School of Medicine
Zhi Yu: Program in Medical and Population Genetics, Broad Institute
Antoine Weihs: University Medicine Greifswald
Anselm Hoppmann: University of Freiburg
Franziska Grundner-Culemann: University of Freiburg
Josine L. Min: University of Bristol
Victoria L. Halperin Kuhns: University of Maryland School of Medicine
Adebowale A. Adeyemo: National Human Genome Research Institute, National Institutes of Health
Charles Agyemang: University of Amsterdam
Johan Ärnlöv: Karolinska Institutet
Nasir A. Aziz: German Centre for Neurodegenerative Diseases (DZNE)
Andrea Baccarelli: Columbia University
Murielle Bochud: University of Lausanne
Hermann Brenner: Division of Clinical Epidemiology and Aging Research
Jan Bressler: School of Public Health, The University of Texas Health Science Center at Houston
Monique M. B. Breteler: German Centre for Neurodegenerative Diseases (DZNE)
Cristian Carmeli: University of Lausanne
Layal Chaker: Erasmus University Medical Center
Josef Coresh: Johns Hopkins Bloomberg School of Public Health
Tanguy Corre: University of Lausanne
Adolfo Correa: University of Mississippi Medical Center
Simon R. Cox: The University of Edinburgh
Graciela E. Delgado: Heidelberg University
Kai-Uwe Eckardt: University of Erlangen-Nürnberg
Arif B. Ekici: Friedrich-Alexander-UniversitätErlangen-Nürnberg
Karlhans Endlich: University Medicine Greifswald
James S. Floyd: University of Washington
Eliza Fraszczyk: University of Groningen, University Medical Center Groningen
Xu Gao: Columbia University
Xīn Gào: Division of Clinical Epidemiology and Aging Research
Allan C. Gelber: Johns Hopkins Bloomberg School of Public Health
Mohsen Ghanbari: Erasmus University Medical Center
Sahar Ghasemi: University Medicine Greifswald
Christian Gieger: German Research Center for Environmental Health
Philip Greenland: Northwestern University Feinberg School of Medicine
Megan L. Grove: School of Public Health, The University of Texas Health Science Center at Houston
Sarah E. Harris: The University of Edinburgh
Gibran Hemani: University of Bristol
Peter Henneman: University of Amsterdam
Christian Herder: Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
Steve Horvath: University of California Los Angeles
Lifang Hou: Northwestern University Feinberg School of Medicine
Mikko A. Hurme: Tampere University
Shih-Jen Hwang: Framingham Heart Study
Sharon L. R. Kardia: University of Michigan
Silva Kasela: University of Tartu
Marcus E. Kleber: Heidelberg University
Wolfgang Koenig: Technische Universität München
Jaspal S. Kooner: Imperial College London
Florian Kronenberg: Medical University of Innsbruck
Brigitte Kühnel: German Research Center for Environmental Health
Christine Ladd-Acosta: Johns Hopkins Bloomberg School of Public Health
Terho Lehtimäki: Tampere University
Lars Lind: Uppsala University
Dan Liu: German Centre for Neurodegenerative Diseases (DZNE)
Donald M. Lloyd-Jones: Northwestern University Feinberg School of Medicine
Stefan Lorkowski: Friedrich Schiller University Jena
Ake T. Lu: University of California Los Angeles
Riccardo E. Marioni: University of Edinburgh
Winfried März: Heidelberg University
Daniel L. McCartney: University of Edinburgh
Karlijn A. C. Meeks: National Human Genome Research Institute, National Institutes of Health
Lili Milani: University of Tartu
Pashupati P. Mishra: Tampere University
Matthias Nauck: Partner Site Greifswald
Christoph Nowak: Karolinska Institutet
Annette Peters: Helmholtz Zentrum München, German Research Center for Environmental Health
Holger Prokisch: Klinikum rechts der Isar, Technische Universität München
Bruce M. Psaty: University of Washington
Olli T. Raitakari: University of Turku
Scott M. Ratliff: University of Michigan
Alex P. Reiner: University of Washington
Ben Schöttker: Division of Clinical Epidemiology and Aging Research
Joel Schwartz: Harvard T.H. Chan School of Public Health
Sanaz Sedaghat: University of Minnesota
Jennifer A. Smith: University of Michigan
Nona Sotoodehnia: University of Washington
Hannah R. Stocker: Division of Clinical Epidemiology and Aging Research
Silvia Stringhini: University of Lausanne
Johan Sundström: Uppsala University
Brenton R. Swenson: University of Washington
Joyce B. J. Meurs: Erasmus Medical Center
Jana V. Vliet-Ostaptchouk: University of Groningen, University Medical Center Groningen
Andrea Venema: University of Amsterdam
Uwe Völker: Partner Site Greifswald
Juliane Winkelmann: Klinikum rechts der Isar, Technische Universität München
Bruce H. R. Wolffenbuttel: University of Groningen, University Medical Center Groningen
Wei Zhao: University of Michigan
Yinan Zheng: Northwestern University Feinberg School of Medicine
Marie Loh: Nanyang Technological University
Harold Snieder: University of Groningen, University Medical Center Groningen
Melanie Waldenberger: German Research Center for Environmental Health
Daniel Levy: Framingham Heart Study
Shreeram Akilesh: University of Washington
Owen M. Woodward: University of Maryland School of Medicine
Katalin Susztak: University of Pennsylvania Perelman School of Medicine
Alexander Teumer: Partner Site Greifswald
Anna Köttgen: Johns Hopkins Bloomberg School of Public Health

Nature Communications, 2021, vol. 12, issue 1, 1-18

Abstract: Abstract Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant (p

Date: 2021
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DOI: 10.1038/s41467-021-27198-4

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