Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis

Diyan Li (), Chunyou Ning, Jiaman Zhang, Yujie Wang, Qianzi Tang, Hua Kui, Tao Wang, Mengnan He, Long Jin, Jing Li, Yu Lin, Bo Zeng, Huadong Yin, Xiaoling Zhao, Yao Zhang, Huailiang Xu, Qing Zhu and Mingzhou Li ()
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Diyan Li: Sichuan Agricultural University
Chunyou Ning: Sichuan Agricultural University
Jiaman Zhang: Sichuan Agricultural University
Yujie Wang: Sichuan Agricultural University
Qianzi Tang: Sichuan Agricultural University
Hua Kui: Sichuan Agricultural University
Tao Wang: Sichuan Agricultural University
Mengnan He: Sichuan Agricultural University
Long Jin: Sichuan Agricultural University
Jing Li: Sichuan Agricultural University
Yu Lin: Sichuan Agricultural University
Bo Zeng: Sichuan Agricultural University
Huadong Yin: Sichuan Agricultural University
Xiaoling Zhao: Sichuan Agricultural University
Yao Zhang: Sichuan Agricultural University
Huailiang Xu: Sichuan Agricultural University
Qing Zhu: Sichuan Agricultural University
Mingzhou Li: Sichuan Agricultural University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Folliculogenesis is a complex biological process involving a central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture is an important transcription regulator; however, little is known about its dynamics and role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic dynamics of chicken granulosa cells over ten follicular stages and assess the chromatin architecture dynamics and how it influences gene expression in granulosa cells at three key stages: the prehierarchical small white follicles, the first largest preovulatory follicles, and the postovulatory follicles. Our results demonstrate the consistency between the global reprogramming of chromatin architecture and the transcriptomic divergence during folliculogenesis, providing ample evidence for compartmentalization rearrangement, variable organization of topologically associating domains, and rewiring of the long-range interaction between promoter and enhancers. These results provide key insights into avian reproductive biology and provide a foundational dataset for the future in-depth functional characterization of granulosa cells.

Date: 2022
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DOI: 10.1038/s41467-021-27800-9

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