Self-reported COVID-19 vaccine hesitancy and uptake among participants from different racial and ethnic groups in the United States and United Kingdom

Long H. Nguyen, Amit D. Joshi, David A. Drew, Jordi Merino, Wenjie Ma, Chun-Han Lo, Sohee Kwon, Kai Wang, Mark S. Graham, Lorenzo Polidori, Cristina Menni, Carole H. Sudre, Adjoa Anyane-Yeboa, Christina M. Astley, Erica T. Warner, Christina Y. Hu, Somesh Selvachandran, Richard Davies, Denis Nash, Paul W. Franks, Jonathan Wolf, Sebastien Ourselin, Claire J. Steves, Tim D. Spector and Andrew T. Chan ()
Additional contact information
Long H. Nguyen: Massachusetts General Hospital and Harvard Medical School
Amit D. Joshi: Massachusetts General Hospital and Harvard Medical School
David A. Drew: Massachusetts General Hospital and Harvard Medical School
Jordi Merino: Massachusetts General Hospital and Harvard Medical School
Wenjie Ma: Massachusetts General Hospital and Harvard Medical School
Chun-Han Lo: Massachusetts General Hospital and Harvard Medical School
Sohee Kwon: Massachusetts General Hospital and Harvard Medical School
Kai Wang: Massachusetts General Hospital and Harvard Medical School
Mark S. Graham: King’s College London
Lorenzo Polidori: Zoe Ltd
Cristina Menni: King’s College London
Carole H. Sudre: King’s College London
Adjoa Anyane-Yeboa: Massachusetts General Hospital and Harvard Medical School
Christina M. Astley: Broad Institute of MIT and Harvard
Erica T. Warner: Massachusetts General Hospital and Harvard Medical School
Christina Y. Hu: Zoe Ltd
Somesh Selvachandran: Zoe Ltd
Denis Nash: City University of New York (CUNY)
Paul W. Franks: Lund University
Jonathan Wolf: Zoe Ltd
Sebastien Ourselin: King’s College London
Claire J. Steves: King’s College London
Tim D. Spector: King’s College London
Andrew T. Chan: Massachusetts General Hospital and Harvard Medical School

Nature Communications, 2022, vol. 13, issue 1, 1-9

Abstract: Abstract Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteered to take part in the smartphone-based COVID Symptom Study (March 2020-February 2021) and used logistic regression to estimate odds ratios of vaccine hesitancy and uptake. In the U.S. (n = 87,388), compared to white participants, vaccine hesitancy was greater for Black and Hispanic participants and those reporting more than one or other race. In the U.K. (n = 1,254,294), racial and ethnic minority participants showed similar levels of vaccine hesitancy to the U.S. However, associations between participant race and ethnicity and levels of vaccine uptake were observed to be different in the U.S. and the U.K. studies. Among U.S. participants, vaccine uptake was significantly lower among Black participants, which persisted among participants that self-reported being vaccine-willing. In contrast, statistically significant racial and ethnic disparities in vaccine uptake were not observed in the U.K sample. In this study of self-reported vaccine hesitancy and uptake, lower levels of vaccine uptake in Black participants in the U.S. during the initial vaccine rollout may be attributable to both hesitancy and disparities in access.

Date: 2022
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DOI: 10.1038/s41467-022-28200-3

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