Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Huaying He, Weikang Zhou, Jing Gao, Fan Wang, Shaobing Wang, Yan Fang (), Yang Gao, Wei Chen (), Wen Zhang, Yunxiang Weng, Zhengchao Wang and Haiqing Liu ()
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Huaying He: Fujian Normal University
Weikang Zhou: Fujian Normal University
Jing Gao: Fujian Normal University
Fan Wang: Fujian Normal University
Shaobing Wang: Fujian Normal University
Yan Fang: Fujian Normal University
Yang Gao: Fujian Normal University
Wei Chen: Fujian Normal University
Wen Zhang: Fujian Normal University
Yunxiang Weng: Fujian Normal University
Zhengchao Wang: Fujian Normal University
Haiqing Liu: Fujian Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat GauzeTM. Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28209-8

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DOI: 10.1038/s41467-022-28209-8

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