Physiological synaptic activity and recognition memory require astroglial glutamine

Giselle Cheung, Danijela Bataveljic, Josien Visser, Naresh Kumar, Julien Moulard, Glenn Dallérac, Daria Mozheiko, Astrid Rollenhagen, Pascal Ezan, Cédric Mongin, Oana Chever, Alexis-Pierre Bemelmans, Joachim Lübke, Isabelle Leray and Nathalie Rouach ()
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Giselle Cheung: Université PSL
Danijela Bataveljic: Université PSL
Josien Visser: Université PSL
Naresh Kumar: Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
Julien Moulard: Université PSL
Glenn Dallérac: Université PSL
Daria Mozheiko: Université PSL
Astrid Rollenhagen: Research Center Jülich
Pascal Ezan: Université PSL
Cédric Mongin: Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
Oana Chever: Université PSL
Alexis-Pierre Bemelmans: Université Paris-Sud, Neurodegenerative Diseases Laboratory
Joachim Lübke: Research Center Jülich
Isabelle Leray: Université Paris Saclay, ENS Paris-Saclay, CNRS, PPSM
Nathalie Rouach: Université PSL

Nature Communications, 2022, vol. 13, issue 1, 1-17

Abstract: Abstract Presynaptic glutamate replenishment is fundamental to brain function. In high activity regimes, such as epileptic episodes, this process is thought to rely on the glutamate-glutamine cycle between neurons and astrocytes. However the presence of an astroglial glutamine supply, as well as its functional relevance in vivo in the healthy brain remain controversial, partly due to a lack of tools that can directly examine glutamine transfer. Here, we generated a fluorescent probe that tracks glutamine in live cells, which provides direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structures under physiological conditions. This mobilization is mediated by connexin43, an astroglial protein with both gap-junction and hemichannel functions, and is essential for synaptic transmission and object recognition memory. Our findings uncover an indispensable recruitment of astroglial glutamine in physiological synaptic activity and memory via an unconventional pathway, thus providing an astrocyte basis for cognitive processes.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28331-7

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DOI: 10.1038/s41467-022-28331-7

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