Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2

Shan Nan Chen, Zhen Gan, Jing Hou, Yue Cong Yang, Lin Huang, Bei Huang, Su Wang and Pin Nie ()
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Shan Nan Chen: Institute of Hydrobiology, Chinese Academy of Sciences
Zhen Gan: Institute of Hydrobiology, Chinese Academy of Sciences
Jing Hou: Institute of Hydrobiology, Chinese Academy of Sciences
Yue Cong Yang: Institute of Hydrobiology, Chinese Academy of Sciences
Lin Huang: Institute of Hydrobiology, Chinese Academy of Sciences
Bei Huang: Institute of Hydrobiology, Chinese Academy of Sciences
Su Wang: Pilot National Laboratory for Marine Science and Technology (Qingdao)
Pin Nie: Institute of Hydrobiology, Chinese Academy of Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. Here we identify IFN-υ from the genomic sequences of vertebrates. The members of class II cytokine receptors, IFN-υR1 and IL-10R2, are identified as the receptor complex of IFN-υ, and are associated with IFN-υ stimulated gene expression and antiviral activity in zebrafish (Danio rerio) and African clawed frog (Xenopus laevis). IFN-υ and IFN-υR1 are separately located at unique and highly conserved loci, being distinct from all other three-type IFNs. IFN-υ and IFN-υR1 are phylogenetically clustered with class II cytokines and class II cytokine receptors, respectively. Therefore, the finding of this IFN ligand-receptor system may be considered as a type IV IFN, in addition to the currently recognized three types of IFNs in vertebrates.

Date: 2022
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DOI: 10.1038/s41467-022-28645-6

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