Clinical and genomic features of Chinese lung cancer patients with germline mutations

Wenying Peng, Bin Li, Jin Li, Lianpeng Chang, Jing Bai, Yuting Yi, Rongrong Chen, Yanyan Zhang, Chen Chen, Xingxiang Pu, Meilin Jiang, Jia Li, Rui Zhong, Fang Xu, Bolin Chen, Li Xu, Ning Wang, Jiaojiao Huan, Pingping Dai, Yanfang Guan, Ling Yang, Xuefeng Xia, Xin Yi, Jiayin Wang, Fenglei Yu () and Lin Wu ()
Additional contact information
Wenying Peng: Central South University
Bin Li: Central South University
Jin Li: Geneplus-Beijing
Lianpeng Chang: Geneplus-Beijing
Jing Bai: Geneplus-Beijing
Yuting Yi: Geneplus-Beijing
Rongrong Chen: Geneplus-Beijing
Yanyan Zhang: Geneplus-Beijing
Chen Chen: Geneplus-Beijing
Xingxiang Pu: Central South University
Meilin Jiang: Central South University
Jia Li: Central South University
Rui Zhong: Central South University
Fang Xu: Central South University
Bolin Chen: Central South University
Li Xu: Central South University
Ning Wang: The PLA Rocket Force Characteristic Medical Center
Jiaojiao Huan: Geneplus-Beijing
Pingping Dai: Geneplus-Beijing
Yanfang Guan: Geneplus-Beijing
Ling Yang: Geneplus-Beijing
Xuefeng Xia: Geneplus-Beijing
Xin Yi: Geneplus-Beijing
Jiayin Wang: Xi’an Jiaotong University
Fenglei Yu: The Second Xiangya Hospital of Central South University
Lin Wu: Central South University

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p

Date: 2022
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DOI: 10.1038/s41467-022-28840-5

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