Genetic variation of macronutrient tolerance in Drosophila melanogaster

E. Havula (), S. Ghazanfar, N. Lamichane, D. Francis, K. Hasygar, Y. Liu, L. A. Alton, J. Johnstone, E. J. Needham, T. Pulpitel, T. Clark, H. N. Niranjan, V. Shang, V. Tong, N. Jiwnani, G. Audia, A. N. Alves, L. Sylow, C. Mirth, G. G. Neely, J. Yang, V. Hietakangas, S. J. Simpson and A. M. Senior ()
Additional contact information
E. Havula: The University of Sydney
S. Ghazanfar: The University of Sydney
N. Lamichane: University of Helsinki
D. Francis: The University of Sydney
K. Hasygar: University of Helsinki
Y. Liu: University of Helsinki
L. A. Alton: Monash University
J. Johnstone: Monash University
E. J. Needham: The University of Sydney
T. Pulpitel: The University of Sydney
T. Clark: The University of Sydney
H. N. Niranjan: The University of Sydney
V. Shang: The University of Sydney
V. Tong: The University of Sydney
N. Jiwnani: The University of Sydney
G. Audia: The University of Sydney
A. N. Alves: Monash University
L. Sylow: University of Copenhagen
C. Mirth: Monash University
G. G. Neely: The University of Sydney
J. Yang: The University of Sydney
V. Hietakangas: University of Helsinki
S. J. Simpson: The University of Sydney
A. M. Senior: The University of Sydney

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a “dietary generalist”, displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-29183-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29183-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-29183-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().