cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors

Cong Liu, Di Sun, Jiawen Liu, Ying Chen, Xuge Zhou, Yunrui Ru, Jingrong Zhu and Weijie Liu ()
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Cong Liu: Jiangsu Normal University
Di Sun: Jiangsu Normal University
Jiawen Liu: Jiangsu Normal University
Ying Chen: Jiangsu Normal University
Xuge Zhou: Jiangsu Normal University
Yunrui Ru: Jiangsu Normal University
Jingrong Zhu: Jiangsu Normal University
Weijie Liu: Jiangsu Normal University

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. There is evidence of cross-talk between pathways mediated by c-di-GMP and those mediated by the cAMP receptor protein (CRP), but the mechanisms are often unclear. Here, we show that cAMP-CRP modulates biofilm maintenance in Shewanella putrefaciens not only via its known effects on gene transcription, but also through direct interaction with a putative c-di-GMP effector on the inner membrane, BpfD. Binding of cAMP-CRP to BpfD enhances the known interaction of BpfD with protease BpfG, which prevents proteolytic processing and release of a cell surface-associated adhesin, BpfA, thus contributing to biofilm maintenance. Our results provide evidence of cross-talk between cAMP and c-di-GMP pathways through direct interaction of their effectors, and indicate that cAMP-CRP can play regulatory roles at the post-translational level.

Date: 2022
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DOI: 10.1038/s41467-022-29240-5

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