Next-generation biomonitoring of the early-life chemical exposome in neonatal and infant development

Thomas Jamnik, Mira Flasch, Dominik Braun, Yasmin Fareed, Daniel Wasinger, David Seki, David Berry, Angelika Berger, Lukas Wisgrill and Benedikt Warth ()
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Thomas Jamnik: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
Mira Flasch: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
Dominik Braun: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
Yasmin Fareed: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
Daniel Wasinger: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology
David Seki: Comprehensive Center for Pediatrics
David Berry: Division of Microbial Ecology, University of Vienna
Angelika Berger: Comprehensive Center for Pediatrics
Lukas Wisgrill: Comprehensive Center for Pediatrics
Benedikt Warth: University of Vienna, Faculty of Chemistry, Department of Food Chemistry and Toxicology

Nature Communications, 2022, vol. 13, issue 1, 1-14

Abstract: Abstract Exposure to synthetic and natural chemicals is a major environmental risk factor in the etiology of many chronic diseases. Investigating complex co-exposures is necessary for a holistic assessment in exposome-wide association studies. In this work, a sensitive liquid chromatography-tandem mass spectrometry approach was developed and validated. The assay enables the analysis of more than 80 highly-diverse xenobiotics in urine, serum/plasma, and breast milk; with detection limits generally in the pg-ng mL−1 range. In plasma of extremely-premature infants, 27 xenobiotics are identified; including contamination with plasticizers, perfluorinated alkylated substances and parabens. In breast milk samples collected longitudinally over the first 211 days post-partum, 29 analytes are detected, including pyrrolizidine- and tropane alkaloids which have not been identified in this matrix before. A preliminary estimation of daily toxicant intake via breast milk is conducted. In conclusion, we observe significant early-life co-exposure to multiple toxicants, and demonstrate the method’s applicability for large-scale exposomics-type cohort studies.

Date: 2022
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DOI: 10.1038/s41467-022-30204-y

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