Mitigation of SARS-CoV-2 transmission at a large public university

Ranoa, Diana Rose E.; Holland, Robin L.; Alnaji, Fadi G.; Green, Kelsie J.; Wang, Leyi; Fredrickson, Richard L.; Wang, Tong; Wong, George N.; Uelmen, Johnny; Maslov, Sergei; Weiner, Zachary J.; Tkachenko, Alexei V.; Zhang, Hantao; Liu, Zhiru; Ibrahim, Ahmed; Patel, Sanjay J.; Paul, John M.; Vance, Nickolas P.; Gulick, Joseph G.; Satheesan, Sandeep Puthanveetil; Galvan, Isaac J.; Miller, Andrew; Grohens, Joseph; Nelson, Todd J.; Stevens, Mary P.; Hennessy, P Mark; Parker, Robert C.; Santos, Edward; Brackett, Charles; Steinman, Julie D.; Fenner, Melvin R.; Dohrer, Kirstin; DeLorenzo, Michael; Wilhelm-Barr, Laura; Brauer, Brian R.; Best-Popescu, Catherine; Durack, Gary; Wetter, Nathan; Kranz, David M.; Breitbarth, Jessica; Simpson, Charlie; Pryde, Julie A.; Kaler, Robin N.; Harris, Chris; Vance, Allison C.; Silotto, Jodi L.; Johnson, Mark; Valera, Enrique Andres; Anton, Patricia K.; Mwilambwe, Lowa; Bryan, Stephen P.; Stone, Deborah S.; Young, Danita B.; Ward, Wanda E.; Lantz, John; Vozenilek, John A.; Bashir, Rashid; Moore, Jeffrey S.; Garg, Mayank; Cooper, Julian C.; Snyder, Gillian; Lore, Michelle H.; Yocum, Dustin L.; Cohen, Neal J.; Novakofski, Jan E.; Loots, Melanie J.; Ballard, Randy L.; Band, Mark; Banks, Kayla M.; Barnes, Joseph D.; Bentea, Iuliana; Black, Jessica; Busch, Jeremy; Conte, Abigail; Conte, Madison; Curry, Michael; Eardley, Jennifer; Edwards, April; Eggett, Therese; Fleurimont, Judes; Foster, Delaney; Fouke, Bruce W.; Gallagher, Nicholas; Gastala, Nicole; Genung, Scott A.; Glueck, Declan; Gray, Brittani; Greta, Andrew; Healy, Robert M.; Hetrick, Ashley; Holterman, Arianna A.; Ismail, Nahed; Jasenof, Ian; Kelly, Patrick; Kielbasa, Aaron; Kiesel, Teresa; Kindle, Lorenzo M.; Lipking, Rhonda L.; Manabe, Yukari C.; Mayes, Jade ́; McGuffin, Reubin; McHenry, Kenton G.; Mirza, Agha; Moseley, Jada; Mostafa, Heba H.; Mumford, Melody; Munoz, Kathleen; Murray, Arika D.; Nolan, Moira; Parikh, Nil A.; Pekosz, Andrew; Pflugmacher, Janna; Phillips, Janise M.; Pitts, Collin; Potter, Mark C.; Quisenberry, James; Rear, Janelle; Robinson, Matthew L.; Rosillo, Edith; Rye, Leslie N.; Sherwood, MaryEllen; Simon, Anna; Singson, Jamie M.; Skadden, Carly; Skelton, Tina H.; Smith, Charlie; Stech, Mary; Thomas, Ryan; Tomaszewski, Matthew A.; Tyburski, Erika A.; Vanwingerden, Scott; Vlach, Evette; Watkins, Ronald S.; Watson, Karriem; White, Karen C.; Killeen, Timothy L.; Jones, Robert J.; Cangellaris, Andreas C.; Martinis, Susan A.; Vaid, Awais; Brooke, Christopher B.; Walsh, Joseph T.; Elbanna, Ahmed; Sullivan, William C.; Smith, Rebecca L.; Goldenfeld, Nigel; Fan, Timothy M.; Hergenrother, Paul J.; Burke, Martin D.

Mitigation of SARS-CoV-2 transmission at a large public university

Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Richard L. Fredrickson, Tong Wang, George N. Wong, Johnny Uelmen, Sergei Maslov, Zachary J. Weiner, Alexei V. Tkachenko, Hantao Zhang, Zhiru Liu, Ahmed Ibrahim, Sanjay J. Patel, John M. Paul, Nickolas P. Vance, Joseph G. Gulick, Sandeep Puthanveetil Satheesan, Isaac J. Galvan, Andrew Miller, Joseph Grohens, Todd J. Nelson, Mary P. Stevens, P Mark Hennessy, Robert C. Parker, Edward Santos, Charles Brackett, Julie D. Steinman, Melvin R. Fenner, Kirstin Dohrer, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R. Brauer, Catherine Best-Popescu, Gary Durack, Nathan Wetter, David M. Kranz, Jessica Breitbarth, Charlie Simpson, Julie A. Pryde, Robin N. Kaler, Chris Harris, Allison C. Vance, Jodi L. Silotto, Mark Johnson, Enrique Andres Valera, Patricia K. Anton, Lowa Mwilambwe, Stephen P. Bryan, Deborah S. Stone, Danita B. Young, Wanda E. Ward, John Lantz, John A. Vozenilek, Rashid Bashir, Jeffrey S. Moore, Mayank Garg, Julian C. Cooper, Gillian Snyder, Michelle H. Lore, Dustin L. Yocum, Neal J. Cohen, Jan E. Novakofski, Melanie J. Loots, Randy L. Ballard, Mark Band, Kayla M. Banks, Joseph D. Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Abigail Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W. Fouke, Nicholas Gallagher, Nicole Gastala, Scott A. Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M. Healy, Ashley Hetrick, Arianna A. Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M. Kindle, Rhonda L. Lipking, Yukari C. Manabe, Jade ́ Mayes, Reubin McGuffin, Kenton G. McHenry, Agha Mirza, Jada Moseley, Heba H. Mostafa, Melody Mumford, Kathleen Munoz, Arika D. Murray, Moira Nolan, Nil A. Parikh, Andrew Pekosz, Janna Pflugmacher, Janise M. Phillips, Collin Pitts, Mark C. Potter, James Quisenberry, Janelle Rear, Matthew L. Robinson, Edith Rosillo, Leslie N. Rye, MaryEllen Sherwood, Anna Simon, Jamie M. Singson, Carly Skadden, Tina H. Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A. Tomaszewski, Erika A. Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S. Watkins, Karriem Watson, Karen C. White, Timothy L. Killeen, Robert J. Jones, Andreas C. Cangellaris, Susan A. Martinis, Awais Vaid, Christopher B. Brooke, Joseph T. Walsh, Ahmed Elbanna (), William C. Sullivan (), Rebecca L. Smith (), Nigel Goldenfeld (), Timothy M. Fan (), Paul J. Hergenrother () and Martin D. Burke ()
Additional contact information
Diana Rose E. Ranoa: University of Illinois at Urbana-Champaign
Robin L. Holland: University of Illinois at Urbana-Champaign
Fadi G. Alnaji: University of Illinois at Urbana-Champaign
Kelsie J. Green: University of Illinois at Urbana-Champaign
Leyi Wang: University of Illinois at Urbana-Champaign
Richard L. Fredrickson: University of Illinois at Urbana-Champaign
Tong Wang: University of Illinois at Urbana-Champaign
George N. Wong: University of Illinois at Urbana-Champaign
Johnny Uelmen: University of Illinois at Urbana-Champaign
Sergei Maslov: University of Illinois at Urbana Champaign
Zachary J. Weiner: University of Illinois at Urbana-Champaign
Alexei V. Tkachenko: Brookhaven National Laboratory
Hantao Zhang: University of Illinois at Urbana-Champaign
Zhiru Liu: Stanford University
Ahmed Ibrahim: University of Illinois at Urbana-Champaign
Sanjay J. Patel: University of Illinois at Urbana-Champaign
John M. Paul: University of Illinois Urbana-Champaign
Nickolas P. Vance: University of Illinois at Urbana-Champaign
Joseph G. Gulick: University of Illinois at Urbana-Champaign
Sandeep Puthanveetil Satheesan: University of Illinois at Urbana-Champaign
Isaac J. Galvan: University of Illinois at Urbana-Champaign
Andrew Miller: University of Illinois at Urbana-Champaign
Joseph Grohens: University of Illinois at Urbana-Champaign
Todd J. Nelson: University of Illinois at Urbana-Champaign
Mary P. Stevens: University of Illinois at Urbana-Champaign
P Mark Hennessy: Inabyte
Robert C. Parker: University of Illinois at Urbana-Champaign
Edward Santos: OSF Healthcare
Charles Brackett: OSF Healthcare
Julie D. Steinman: University of Illinois at Urbana-Champaign
Melvin R. Fenner: University of Illinois at Urbana-Champaign
Kirstin Dohrer: University of Illinois at Urbana-Champaign
Michael DeLorenzo: University of Illinois at Urbana-Champaign
Laura Wilhelm-Barr: University of Illinois at Urbana-Champaign
Brian R. Brauer: Illinois Fire Service Institute
Catherine Best-Popescu: University of Illinois at Urbana-Champaign
Gary Durack: University of Illinois Urbana-Champaign
Nathan Wetter: Tekmill
David M. Kranz: University of Illinois at Urbana-Champaign
Jessica Breitbarth: University of Illinois at Urbana-Champaign
Charlie Simpson: University of Illinois at Urbana-Champaign
Julie A. Pryde: Champaign-Urbana Public Health District
Robin N. Kaler: University of Illinois at Urbana-Champaign
Chris Harris: University of Illinois at Urbana-Champaign
Allison C. Vance: University of Illinois at Urbana-Champaign
Jodi L. Silotto: University of Illinois at Urbana-Champaign
Mark Johnson: University of Illinois at Urbana-Champaign
Enrique Andres Valera: University of Illinois at Urbana-Champaign
Patricia K. Anton: University of Illinois Urbana-Champaign
Lowa Mwilambwe: University of Illinois Urbana-Champaign
Stephen P. Bryan: University of Illinois at Urbana-Champaign
Deborah S. Stone: University of Illinois at Urbana-Champaign
Danita B. Young: University of Illinois Urbana-Champaign
Wanda E. Ward: University of Illinois at Urbana-Champaign
John Lantz: University of Illinois at Urbana-Champaign
John A. Vozenilek: University of Illinois Urbana-Champaign
Rashid Bashir: University of Illinois Urbana-Champaign
Jeffrey S. Moore: University of Illinois at Urbana Champaign
Mayank Garg: University of Illinois at Urbana-Champaign
Julian C. Cooper: University of Illinois at Urbana-Champaign
Gillian Snyder: University of Illinois at Urbana-Champaign
Michelle H. Lore: University of Illinois at Urbana-Champaign
Dustin L. Yocum: University of Illinois at Urbana-Champaign
Neal J. Cohen: University of Illinois at Urbana-Champaign
Jan E. Novakofski: University of Illinois at Urbana-Champaign
Melanie J. Loots: University of Illinois at Urbana-Champaign
Randy L. Ballard: University of Illinois at Urbana-Champaign
Mark Band: University of Illinois at Urbana-Champaign
Kayla M. Banks: University of Illinois at Urbana-Champaign
Joseph D. Barnes: University of Illinois Health
Iuliana Bentea: University of Illinois at Chicago
Jessica Black: University of Illinois Urbana-Champaign
Jeremy Busch: University of Illinois at Urbana-Champaign
Abigail Conte: Johns Hopkins Bloomberg School of Public Health
Madison Conte: Johns Hopkins School of Medicine
Michael Curry: University of Illinois Urbana-Champaign
Jennifer Eardley: University of Illinois at Urbana-Champaign
April Edwards: University of Illinois at Urbana-Champaign
Therese Eggett: University of Illinois at Urbana-Champaign
Judes Fleurimont: University of Illinois Health
Delaney Foster: University of Illinois at Urbana-Champaign
Bruce W. Fouke: University of Illinois at Urbana Champaign
Nicholas Gallagher: Johns Hopkins University School of Medicine
Nicole Gastala: Johns Hopkins Bloomberg School of Public Health
Scott A. Genung: University of Illinois at Urbana-Champaign
Declan Glueck: University of Illinois Urbana-Champaign
Brittani Gray: University of Illinois Health
Andrew Greta: University of Illinois System Office
Robert M. Healy: University of Illinois at Urbana-Champaign
Ashley Hetrick: University of Wisconsin-Madison
Arianna A. Holterman: University of Illinois at Urbana-Champaign
Nahed Ismail: University of Illinois at Chicago
Ian Jasenof: University of Illinois Health
Patrick Kelly: University of Wisconsin-Madison
Aaron Kielbasa: University of Illinois at Urbana-Champaign
Teresa Kiesel: University of Wisconsin-Madison
Lorenzo M. Kindle: University of Illinois at Urbana-Champaign
Rhonda L. Lipking: University of Illinois at Urbana-Champaign
Yukari C. Manabe: Johns Hopkins School of Medicine
Jade ́ Mayes: University of Illinois at Urbana-Champaign
Reubin McGuffin: University of Illinois at Urbana-Champaign
Kenton G. McHenry: University of Illinois at Urbana-Champaign
Agha Mirza: Johns Hopkins School of Medicine
Jada Moseley: University of Illinois Urbana-Champaign
Heba H. Mostafa: Johns Hopkins University School of Medicine
Melody Mumford: University of Illinois Health
Kathleen Munoz: University of Illinois Health
Arika D. Murray: University of Illinois Urbana-Champaign
Moira Nolan: University of Illinois at Urbana-Champaign
Nil A. Parikh: University of Illinois at Urbana-Champaign
Andrew Pekosz: Johns Hopkins Bloomberg School of Public Health
Janna Pflugmacher: University Administration, University of Illinois at Urbana-Champaign
Janise M. Phillips: University of Illinois at Urbana-Champaign
Collin Pitts: University of Wisconsin-Madison
Mark C. Potter: University of Illinois at Chicago
James Quisenberry: University of Illinois at Urbana-Champaign
Janelle Rear: University of Illinois System
Matthew L. Robinson: Johns Hopkins School of Medicine
Edith Rosillo: University of Illinois at Urbana-Champaign
Leslie N. Rye: University of Illinois at Urbana-Champaign
MaryEllen Sherwood: University of Illinois at Urbana-Champaign
Anna Simon: University of Illinois at Urbana-Champaign
Jamie M. Singson: University of Illinois at Urbana-Champaign
Carly Skadden: University of Illinois at Urbana-Champaign
Tina H. Skelton: University of Illinois at Urbana-Champaign
Charlie Smith: University of Illinois at Urbana-Champaign
Mary Stech: University of Illinois at Urbana-Champaign
Ryan Thomas: University of Illinois at Urbana-Champaign
Matthew A. Tomaszewski: University of Illinois at Urbana-Champaign
Erika A. Tyburski: Children’s Healthcare of Atlanta, and Georgia Institute of Technology
Scott Vanwingerden: University of Illinois at Urbana-Champaign
Evette Vlach: University of Illinois at Urbana-Champaign
Ronald S. Watkins: University of Illinois System Office
Karriem Watson: University of Illinois Health
Karen C. White: University of Illinois at Urbana-Champaign
Timothy L. Killeen: University of Illinois Urbana-Champaign
Robert J. Jones: University of Illinois at Urbana-Champaign
Andreas C. Cangellaris: University of Illinois Urbana-Champaign
Susan A. Martinis: University of Illinois at Urbana-Champaign
Awais Vaid: Champaign-Urbana Public Health District
Christopher B. Brooke: University of Illinois at Urbana Champaign
Joseph T. Walsh: University of Illinois at Urbana-Champaign
Ahmed Elbanna: University of Illinois at Urbana-Champaign
William C. Sullivan: University of Illinois at Urbana-Champaign
Rebecca L. Smith: University of Illinois at Urbana Champaign
Nigel Goldenfeld: University of Illinois at Urbana Champaign
Timothy M. Fan: University of Illinois at Urbana-Champaign
Paul J. Hergenrother: University of Illinois at Urbana-Champaign
Martin D. Burke: University of Illinois at Urbana-Champaign

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SHIELD: Target, Test, and Tell” program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.

Date: 2022
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DOI: 10.1038/s41467-022-30833-3

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