Cooperative chalcogen bonding interactions in confined sites activate aziridines

Haofu Zhu, Pan-Pan Zhou () and Yao Wang ()
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Haofu Zhu: Shandong University
Pan-Pan Zhou: Lanzhou University
Yao Wang: Shandong University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract The activation of aziridines typically involves the use of strong Lewis acids or transition metals, and methods relying on weak interactions are rare. Herein, we report that cooperative chalcogen bonding interactions in confined sites can activate sulfonyl-protected aziridines. Among the several possible distinct bonding modes, our experiments and computational studies suggest that an activation mode involving the cooperative Se···O and Se···N interactions is in operation. The catalytic reactions between weakly bonded supramolecular species and nonactivated alkenes are considered as unfavorable approaches. However, here we show that the activation of aziridines by cooperative Se···O and Se···N interactions enables the cycloaddition of weakly bonded aziridine-selenide complex with nonactivated alkenes in a catalytic manner. Thus, weak interactions can indeed enable these transformations and are an alternative to methods relying on strong Lewis acids.

Date: 2022
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DOI: 10.1038/s41467-022-31293-5

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