MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake

Ruiling Liu, Cuilian Liu, Xiaozhen He, Peng Sun, Bin Zhang, Haoran Yang, Weiyun Shi () and Qingguo Ruan ()
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Ruiling Liu: Qingdao University
Cuilian Liu: Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Xiaozhen He: Shandong First Medical University & Shandong Academy of Medical Sciences
Peng Sun: The Affiliated Hospital of Qingdao University
Bin Zhang: Shandong First Medical University & Shandong Academy of Medical Sciences
Haoran Yang: Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Weiyun Shi: Shandong First Medical University & Shandong Academy of Medical Sciences
Qingguo Ruan: Shandong First Medical University & Shandong Academy of Medical Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Pancreatic β cell dysfunction contributes to the pathogenesis of type 2 diabetes. MiR-21 has been shown to be induced in the islets of glucose intolerant patients and type 2 diabetic mice. However, the role of miR-21 in the regulation of pancreatic β cell function remains largely elusive. In the current study, we identify the pathway by which miR-21 regulates glucose-stimulated insulin secretion utilizing mice lacking miR-21 in their β cells (miR-21βKO). We find that miR-21βKO mice develop glucose intolerance due to impaired glucose-stimulated insulin secretion. Mechanistic studies reveal that miR-21 enhances glucose uptake and subsequently promotes insulin secretion by up-regulating Glut2 expression in a miR-21-Pdcd4-AP-1 dependent pathway. Over-expression of Glut2 in knockout islets results in rescue of the impaired glucose-stimulated insulin secretion. Furthermore, we demonstrate that delivery of miR-21 into the pancreas of type 2 diabetic db/db male mice is able to promote Glut2 expression and reduce blood glucose level. Taking together, our results reveal that miR-21 in islet β cell promotes insulin secretion and support a role for miR-21 in the regulation of pancreatic β cell function in type 2 diabetes.

Date: 2022
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DOI: 10.1038/s41467-022-31317-0

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