Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

Patrick A. Jonge, Koen Wortelboer, Torsten P. M. Scheithauer, Bert-Jan H. Born, Aeilko H. Zwinderman, Franklin L. Nobrega, Bas E. Dutilh, Max Nieuwdorp and Hilde Herrema ()
Additional contact information
Patrick A. Jonge: Amsterdam University Medical Centers, Location AMC
Koen Wortelboer: Amsterdam University Medical Centers, Location AMC
Torsten P. M. Scheithauer: Amsterdam University Medical Centers, Location AMC
Bert-Jan H. Born: Amsterdam University Medical Centers, Location AMC
Aeilko H. Zwinderman: Amsterdam University Medical Centers, Location AMC, University of Amsterdam
Franklin L. Nobrega: University of Southampton
Bas E. Dutilh: Utrecht University
Max Nieuwdorp: Amsterdam University Medical Centers, Location AMC
Hilde Herrema: Amsterdam University Medical Centers, Location AMC

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract There is significant interest in altering the course of cardiometabolic disease development via gut microbiomes. Nevertheless, the highly abundant phage members of the complex gut ecosystem -which impact gut bacteria- remain understudied. Here, we show gut virome changes associated with metabolic syndrome (MetS), a highly prevalent clinical condition preceding cardiometabolic disease, in 196 participants by combined sequencing of bulk whole genome and virus like particle communities. MetS gut viromes exhibit decreased richness and diversity. They are enriched in phages infecting Streptococcaceae and Bacteroidaceae and depleted in those infecting Bifidobacteriaceae. Differential abundance analysis identifies eighteen viral clusters (VCs) as significantly associated with either MetS or healthy viromes. Among these are a MetS-associated Roseburia VC that is related to healthy control-associated Faecalibacterium and Oscillibacter VCs. Further analysis of these VCs revealed the Candidatus Heliusviridae, a highly widespread gut phage lineage found in 90+% of participants. The identification of the temperate Ca. Heliusviridae provides a starting point to studies of phage effects on gut bacteria and the role that this plays in MetS.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-022-31390-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31390-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-31390-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().