Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

Thomas Obadia, Gladys Gutierrez-Bugallo, Veasna Duong, Ana I. Nuñez, Rosilainy S. Fernandes, Basile Kamgang, Liza Hery, Yann Gomard, Sandra R. Abbo, Davy Jiolle, Uros Glavinic, Myrielle Dupont-Rouzeyrol, Célestine M. Atyame, Nicolas Pocquet, Sébastien Boyer, Catherine Dauga, Marie Vazeille, André Yébakima, Michael T. White, Constantianus J. M. Koenraadt, Patrick Mavingui, Anubis Vega-Rua, Eva Veronesi, Gorben P. Pijlman, Christophe Paupy, Núria Busquets, Ricardo Lourenço- de-Oliveira, Xavier Lamballerie and Anna-Bella Failloux ()
Additional contact information
Thomas Obadia: Institut Pasteur, Université Paris Cité, Bioinformatics and Biostatistics Hub
Gladys Gutierrez-Bugallo: Institute of Tropical Medicine Pedro Kouri
Veasna Duong: Institut Pasteur du Cambodge, Virology Unit
Ana I. Nuñez: IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona
Rosilainy S. Fernandes: Laboratorio de Mosquitos Transmissores de Hematozoarios, Instituto Oswaldo Cruz, Fiocruz
Basile Kamgang: Centre for Research in Infectious Diseases, Department of Medical Entomology
Liza Hery: Unit Transmission Reservoir and Pathogens Diversity
Yann Gomard: UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical), Sainte-Clotilde
Sandra R. Abbo: Wageningen University
Davy Jiolle: IRD, MIVEGEC, University of Montpellier, IRD, CNRS
Uros Glavinic: University of Zürich
Myrielle Dupont-Rouzeyrol: Institut Pasteur de Nouvelle-Calédonie, URE Dengue et Arboviroses
Célestine M. Atyame: UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical), Sainte-Clotilde
Nicolas Pocquet: Institut Pasteur de Nouvelle-Calédonie, URE Entomologie Médicale
Sébastien Boyer: Institut Pasteur du Cambodge, Medical Entomology Unit
Catherine Dauga: Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors
Marie Vazeille: Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors
André Yébakima: VECCOTRA
Michael T. White: Institut Pasteur, Université Paris Cité, G5 Infectious Disease Epidemiology and Analytics
Constantianus J. M. Koenraadt: Wageningen University & Research
Patrick Mavingui: UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical), Sainte-Clotilde
Anubis Vega-Rua: Unit Transmission Reservoir and Pathogens Diversity
Eva Veronesi: University of Zürich
Gorben P. Pijlman: Wageningen University
Christophe Paupy: IRD, MIVEGEC, University of Montpellier, IRD, CNRS
Núria Busquets: IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona
Ricardo Lourenço- de-Oliveira: Laboratorio de Mosquitos Transmissores de Hematozoarios, Instituto Oswaldo Cruz, Fiocruz
Xavier Lamballerie: Unité des Virus Emergents (UVE), Aix Marseille Université, IHU Méditerranée Infection
Anna-Bella Failloux: Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors

Nature Communications, 2022, vol. 13, issue 1, 1-8

Abstract: Abstract First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika.

Date: 2022
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DOI: 10.1038/s41467-022-32234-y

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