Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice

Adeeti Aggarwal, Connor Brennan, Jennifer Luo, Helen Chung, Diego Contreras, Max B. Kelz and Alex Proekt ()
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Adeeti Aggarwal: University of Pennsylvania
Connor Brennan: University of Pennsylvania
Jennifer Luo: University of Pennsylvania
Helen Chung: University of Pennsylvania
Diego Contreras: University of Pennsylvania
Max B. Kelz: University of Pennsylvania
Alex Proekt: University of Pennsylvania

Nature Communications, 2022, vol. 13, issue 1, 1-16

Abstract: Abstract Sensory processing is distributed among many brain regions that interact via feedforward and feedback signaling. Neuronal oscillations have been shown to mediate intercortical feedforward and feedback interactions. Yet, the macroscopic structure of the multitude of such oscillations remains unclear. Here, we show that simple visual stimuli reliably evoke two traveling waves with spatial wavelengths that cover much of the cerebral hemisphere in awake mice. 30-50 Hz feedforward waves arise in primary visual cortex (V1) and propagate rostrally, while 3-6 Hz feedback waves originate in the association cortex and flow caudally. The phase of the feedback wave modulates the amplitude of the feedforward wave and synchronizes firing between V1 and parietal cortex. Altogether, these results provide direct experimental evidence that visual evoked traveling waves percolate through the cerebral cortex and coordinate neuronal activity across broadly distributed networks mediating visual processing.

Date: 2022
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DOI: 10.1038/s41467-022-32378-x

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