WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions

Nataliia Konstantinova, Lukas Hoermayer, Matouš Glanc, Rabab Keshkeih, Shutang Tan, Martin Donato, Katarzyna Retzer, Jeanette Moulinier-Anzola, Max Schwihla, Barbara Korbei, Markus Geisler, Jiří Friml and Christian Luschnig ()
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Nataliia Konstantinova: University of Natural Resources and Life Sciences
Lukas Hoermayer: Institute of Science and Technology Austria (IST Austria)
Matouš Glanc: Ghent University
Rabab Keshkeih: University of Natural Resources and Life Sciences
Shutang Tan: Institute of Science and Technology Austria (IST Austria)
Martin Donato: University of Fribourg
Katarzyna Retzer: University of Natural Resources and Life Sciences
Jeanette Moulinier-Anzola: University of Natural Resources and Life Sciences
Max Schwihla: University of Natural Resources and Life Sciences
Barbara Korbei: University of Natural Resources and Life Sciences
Markus Geisler: University of Fribourg
Jiří Friml: Institute of Science and Technology Austria (IST Austria)
Christian Luschnig: University of Natural Resources and Life Sciences

Nature Communications, 2022, vol. 13, issue 1, 1-12

Abstract: Abstract Directionality in the intercellular transport of the plant hormone auxin is determined by polar plasma membrane localization of PIN-FORMED (PIN) auxin transport proteins. However, apart from PIN phosphorylation at conserved motifs, no further determinants explicitly controlling polar PIN sorting decisions have been identified. Here we present Arabidopsis WAVY GROWTH 3 (WAV3) and closely related RING-finger E3 ubiquitin ligases, whose loss-of-function mutants show a striking apical-to-basal polarity switch in PIN2 localization in root meristem cells. WAV3 E3 ligases function as essential determinants for PIN polarity, acting independently from PINOID/WAG-dependent PIN phosphorylation. They antagonize ectopic deposition of de novo synthesized PIN proteins already immediately following completion of cell division, presumably via preventing PIN sorting into basal, ARF GEF-mediated trafficking. Our findings reveal an involvement of E3 ligases in the selective targeting of apically localized PINs in higher plants.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32888-8

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DOI: 10.1038/s41467-022-32888-8

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