Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome

Qinnan Yang, Mallory Haute, Nate Korth, Scott E. Sattler, John Toy, Devin J. Rose, James C. Schnable and Andrew K. Benson ()
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Qinnan Yang: University of Nebraska
Mallory Haute: University of Nebraska
Nate Korth: University of Nebraska
Scott E. Sattler: Wheat, Sorghum and Forage Research Unit, USDA-ARS
John Toy: Wheat, Sorghum and Forage Research Unit, USDA-ARS
Devin J. Rose: University of Nebraska
James C. Schnable: University of Nebraska
Andrew K. Benson: University of Nebraska

Nature Communications, 2022, vol. 13, issue 1, 1-15

Abstract: Abstract Prebiotic fibers, polyphenols and other molecular components of food crops significantly affect the composition and function of the human gut microbiome and human health. The abundance of these, frequently uncharacterized, microbiome-active components vary within individual crop species. Here, we employ high throughput in vitro fermentations of pre-digested grain using a human microbiome to identify segregating genetic loci in a food crop, sorghum, that alter the composition and function of human gut microbes. Evaluating grain produced by 294 sorghum recombinant inbreds identifies 10 loci in the sorghum genome associated with variation in the abundance of microbial taxa and/or microbial metabolites. Two loci co-localize with sorghum genes regulating the biosynthesis of condensed tannins. We validate that condensed tannins stimulate the growth of microbes associated with these two loci. Our work illustrates the potential for genetic analysis to systematically discover and characterize molecular components of food crops that influence the human gut microbiome.

Date: 2022
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DOI: 10.1038/s41467-022-33419-1

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