Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing

Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, Xishen Xu, Zhaokui Jin and Qianjun He ()
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Shengqiang Chen: Shenzhen University
Yanxia Zhu: Shenzhen University Health Science Center
Qingqing Xu: Shenzhen University
Qi Jiang: Shenzhen University
Danyang Chen: Shanghai Jiao Tong University
Ting Chen: Shenzhen University
Xishen Xu: Shenzhen University
Zhaokui Jin: Shenzhen University
Qianjun He: Shenzhen University

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose microenvironment, limiting the outcome of DFU therapy. In this work, photocatalytic therapy of diabetic wound is proposed for sustainable hydrogen generation and local glucose depletion by utilizing glucose in the high-glucose microenvironment as a sacrificial agent. Hydrogen-incorporated titanium oxide nanorods are developed to realize efficient visible light (VIS)-responsive photocatalysis for glucose depletion and hydrogen generation, achieving a high efficacy of diabetic wound healing. Mechanistically, local glucose depletion and hydrogen generation jointly attenuate the apoptosis of skin cells and promote their proliferation and migration by inhibiting the synthesis of advanced glycation end products and the expression of their receptors, respectively. The proposed VIS-photocatalytic strategy provides a solution for facile, safe and efficient treatment of DFU.

Date: 2022
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DOI: 10.1038/s41467-022-33475-7

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