Gut microbiome-wide association study of depressive symptoms

Djawad Radjabzadeh, Jos A. Bosch, André G. Uitterlinden, Aeilko H. Zwinderman, M. Arfan Ikram, Joyce B. J. Meurs, Annemarie I. Luik, Max Nieuwdorp, Anja Lok, Cornelia M. Duijn, Robert Kraaij () and Najaf Amin ()
Additional contact information
Djawad Radjabzadeh: Erasmus Medical Center Rotterdam
Jos A. Bosch: University of Amsterdam
André G. Uitterlinden: Erasmus Medical Center Rotterdam
Aeilko H. Zwinderman: Amsterdam University Medical Centers
M. Arfan Ikram: Erasmus MC University Medical Center Rotterdam
Joyce B. J. Meurs: Erasmus Medical Center Rotterdam
Annemarie I. Luik: Erasmus MC University Medical Center Rotterdam
Max Nieuwdorp: Amsterdam University Medical Centers, Location AMC
Anja Lok: Location AMC
Cornelia M. Duijn: Erasmus MC University Medical Center Rotterdam
Robert Kraaij: Erasmus Medical Center Rotterdam
Najaf Amin: Erasmus MC University Medical Center Rotterdam

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract Depression is one of the most poorly understood diseases due to its elusive pathogenesis. There is an urgency to identify molecular and biological mechanisms underlying depression and the gut microbiome is a novel area of interest. Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup, and family Ruminococcaceae with depressive symptoms. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests that the gut microbiome composition may play a key role in depression.

Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-022-34502-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34502-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-022-34502-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().