Ultrasensitive rapid cytokine sensors based on asymmetric geometry two-dimensional MoS2 diodes

Thushani Silva, Mirette Fawzy, Amirhossein Hasani, Hamidreza Ghanbari, Amin Abnavi, Abdelrahman Askar, Yue Ling, Mohammad Reza Mohammadzadeh, Fahmid Kabir, Ribwar Ahmadi, Miriam Rosin, Karen L. Kavanagh and Michael M. Adachi ()
Additional contact information
Thushani Silva: Simon Fraser University
Mirette Fawzy: Simon Fraser University
Amirhossein Hasani: Simon Fraser University
Hamidreza Ghanbari: Simon Fraser University
Amin Abnavi: Simon Fraser University
Abdelrahman Askar: Simon Fraser University
Yue Ling: Simon Fraser University
Mohammad Reza Mohammadzadeh: Simon Fraser University
Fahmid Kabir: Simon Fraser University
Ribwar Ahmadi: Simon Fraser University
Miriam Rosin: Simon Fraser University
Karen L. Kavanagh: Simon Fraser University
Michael M. Adachi: Simon Fraser University

Nature Communications, 2022, vol. 13, issue 1, 1-10

Abstract: Abstract The elevation of cytokine levels in body fluids has been associated with numerous health conditions. The detection of these cytokine biomarkers at low concentrations may help clinicians diagnose diseases at an early stage. Here, we report an asymmetric geometry MoS2 diode-based biosensor for rapid, label-free, highly sensitive, and specific detection of tumor necrosis factor-α (TNF-α), a proinflammatory cytokine. This sensor is functionalized with TNF-α binding aptamers to detect TNF-α at concentrations as low as 10 fM, well below the typical concentrations found in healthy blood. Interactions between aptamers and TNF-α at the sensor surface induce a change in surface energy that alters the current-voltage rectification behavior of the MoS2 diode, which can be read out using a two-electrode configuration. The key advantages of this diode sensor are the simple fabrication process and electrical readout, and therefore, the potential to be applied in a rapid and easy-to-use, point-of-care, diagnostic tool.

Date: 2022
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DOI: 10.1038/s41467-022-35278-2

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