Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives

Bei Huang, Steven W. H. Chau, Yaping Liu, Joey W. Y. Chan, Jing Wang, Suk Ling Ma, Jihui Zhang, Paul K. S. Chan, Yun Kit Yeoh, Zigui Chen, Li Zhou, Sunny Hei Wong, Vincent C. T. Mok, Ka Fai To, Hei Ming Lai, Simon Ng, Claudia Trenkwalder, Francis K. L. Chan and Yun Kwok Wing ()
Additional contact information
Bei Huang: The Chinese University of Hong Kong
Steven W. H. Chau: The Chinese University of Hong Kong
Yaping Liu: The Chinese University of Hong Kong
Joey W. Y. Chan: The Chinese University of Hong Kong
Jing Wang: The Chinese University of Hong Kong
Suk Ling Ma: The Chinese University of Hong Kong
Jihui Zhang: The Chinese University of Hong Kong
Paul K. S. Chan: The Chinese University of Hong Kong
Yun Kit Yeoh: The Chinese University of Hong Kong
Zigui Chen: The Chinese University of Hong Kong
Li Zhou: The Chinese University of Hong Kong
Sunny Hei Wong: The Chinese University of Hong Kong
Vincent C. T. Mok: The Chinese University of Hong Kong
Ka Fai To: The Chinese University of Hong Kong
Hei Ming Lai: The Chinese University of Hong Kong
Simon Ng: The Chinese University of Hong Kong
Claudia Trenkwalder: University Medical Center, Georg August University Göttingen
Francis K. L. Chan: The Chinese University of Hong Kong
Yun Kwok Wing: The Chinese University of Hong Kong

Nature Communications, 2023, vol. 14, issue 1, 1-13

Abstract: Abstract The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.

Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-38248-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38248-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-38248-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().