Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury

Ao Fang, Yifan Wang, Naiyu Guan, Yanming Zuo, Lingmin Lin, Binjie Guo, Aisheng Mo, Yile Wu, Xurong Lin, Wanxiong Cai, Xiangfeng Chen, Jingjia Ye, Zeinab Abdelrahman, Xiaodan Li, Hanyu Zheng, Zhonghan Wu, Shuang Jin, Kan Xu, Yan Huang, Xiaosong Gu, Bin Yu and Xuhua Wang ()
Additional contact information
Ao Fang: Zhejiang University School of Medicine
Yifan Wang: Zhejiang University School of Medicine
Naiyu Guan: Zhejiang University School of Medicine
Yanming Zuo: Zhejiang University School of Medicine
Lingmin Lin: Zhejiang University
Binjie Guo: Zhejiang University
Aisheng Mo: Zhejiang University
Yile Wu: Zhejiang University
Xurong Lin: Zhejiang University
Wanxiong Cai: Zhejiang University
Xiangfeng Chen: Zhejiang University
Jingjia Ye: Zhejiang University
Zeinab Abdelrahman: Zhejiang University School of Medicine
Xiaodan Li: Zhejiang University School of Medicine
Hanyu Zheng: Zhejiang University
Zhonghan Wu: Zhejiang University
Shuang Jin: Zhejiang University
Kan Xu: Zhejiang University
Yan Huang: Medical School of Nantong University
Xiaosong Gu: Nantong University
Bin Yu: Nantong University
Xuhua Wang: Zhejiang University School of Medicine

Nature Communications, 2023, vol. 14, issue 1, 1-17

Abstract: Abstract The transplantation of mesenchymal stem cells-derived secretome, particularly extracellular vesicles is a promising therapy to suppress spinal cord injury-triggered neuroinflammation. However, efficient delivery of extracellular vesicles to the injured spinal cord, with minimal damage, remains a challenge. Here we present a device for the delivery of extracellular vesicles to treat spinal cord injury. We show that the device incorporating mesenchymal stem cells and porous microneedles enables the delivery of extracellular vesicles. We demonstrate that topical application to the spinal cord lesion beneath the spinal dura, does not damage the lesion. We evaluate the efficacy of our device in a contusive spinal cord injury model and find that it reduces the cavity and scar tissue formation, promotes angiogenesis, and improves survival of nearby tissues and axons. Importantly, the sustained delivery of extracellular vesicles for at least 7 days results in significant functional recovery. Thus, our device provides an efficient and sustained extracellular vesicles delivery platform for spinal cord injury treatment.

Date: 2023
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DOI: 10.1038/s41467-023-39745-2

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