Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64

Ruobing Wang, Anru Zhang, Shijun Sun, Guankun Yin, Xingyu Wu, Qi Ding, Qi Wang, Fengning Chen, Shuyi Wang, Lucy Dorp, Yawei Zhang, Longyang Jin, Xiaojuan Wang, Francois Balloux and Hui Wang ()
Additional contact information
Ruobing Wang: Peking University People’s Hospital
Anru Zhang: Peking University People’s Hospital
Shijun Sun: Peking University People’s Hospital
Guankun Yin: Peking University People’s Hospital
Xingyu Wu: Peking University People’s Hospital
Qi Ding: Peking University People’s Hospital
Qi Wang: Peking University People’s Hospital
Fengning Chen: Peking University People’s Hospital
Shuyi Wang: Peking University People’s Hospital
Lucy Dorp: University College London
Yawei Zhang: Peking University People’s Hospital
Longyang Jin: Peking University People’s Hospital
Xiaojuan Wang: Peking University People’s Hospital
Francois Balloux: University College London
Hui Wang: Peking University People’s Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The acquisition of exogenous mobile genetic material imposes an adaptive burden on bacteria, whereas the adaptational evolution of virulence plasmids upon entry into carbapenem-resistant Klebsiella pneumoniae (CRKP) and its impact remains unclear. To better understand the virulence in CRKP, we characterize virulence plasmids utilizing a large genomic data containing 1219 K. pneumoniae from our long-term surveillance and publicly accessible databases. Phylogenetic evaluation unveils associations between distinct virulence plasmids and serotypes. The sub-lineage ST11-KL64 CRKP acquires a pK2044-like virulence plasmid from ST23-KL1 hypervirulent K. pneumoniae, with a 2698 bp region deletion in all ST11-KL64. The deletion is observed to regulate methionine metabolism, enhance antioxidant capacity, and further improve survival of hypervirulent CRKP in macrophages. The pK2044-like virulence plasmid discards certain sequences to enhance survival of ST11-KL64, thereby conferring an evolutionary advantage. This work contributes to multifaceted understanding of virulence and provides insight into potential causes behind low fitness costs observed in bacteria.

Date: 2024
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DOI: 10.1038/s41467-023-44351-3

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