A self-powered intracardiac pacemaker in swine model

Zhuo Liu, Yiran Hu, Xuecheng Qu, Ying Liu, Sijing Cheng, Zhengmin Zhang, Yizhu Shan, Ruizeng Luo, Sixian Weng, Hui Li, Hongxia Niu, Min Gu, Yan Yao, Bojing Shi, Ningning Wang (), Wei Hua (), Zhou Li () and Zhong Lin Wang
Additional contact information
Zhuo Liu: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Yiran Hu: Chinese Academy of Medical Sciences and Peking Union Medical College
Xuecheng Qu: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Ying Liu: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Sijing Cheng: Chinese Academy of Medical Sciences and Peking Union Medical College
Zhengmin Zhang: Hangzhou Dianzi University
Yizhu Shan: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Ruizeng Luo: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Sixian Weng: Chinese Academy of Medical Sciences and Peking Union Medical College
Hui Li: Chinese Academy of Medical Sciences and Peking Union Medical College
Hongxia Niu: Chinese Academy of Medical Sciences and Peking Union Medical College
Min Gu: Chinese Academy of Medical Sciences and Peking Union Medical College
Yan Yao: Capital Medical University
Bojing Shi: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Ningning Wang: Hangzhou Dianzi University
Wei Hua: Chinese Academy of Medical Sciences and Peking Union Medical College
Zhou Li: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Zhong Lin Wang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Harvesting biomechanical energy from cardiac motion is an attractive power source for implantable bioelectronic devices. Here, we report a battery-free, transcatheter, self-powered intracardiac pacemaker based on the coupled effect of triboelectrification and electrostatic induction for the treatment of arrhythmia in large animal models. We show that the capsule-shaped device (1.75 g, 1.52 cc) can be integrated with a delivery catheter for implanting in the right ventricle of a swine through the intravenous route, which effectively converts cardiac motion energy to electricity and maintains endocardial pacing function during the three-week follow-up period. We measure in vivo open circuit voltage and short circuit current of the self-powered intracardiac pacemaker of about 6.0 V and 0.2 μA, respectively. This approach exhibits up-to-date progress in self-powered medical devices and it may overcome the inherent energy shortcomings of implantable pacemakers and other bioelectronic devices for therapy and sensing.

Date: 2024
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DOI: 10.1038/s41467-023-44510-6

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