Digital automation of transdermal drug delivery with high spatiotemporal resolution

Yihang Wang, Zeka Chen, Brayden Davis, Will Lipman, Sicheng Xing, Lin Zhang, Tian Wang, Priyash Hafiz, Wanrong Xie, Zijie Yan, Zhili Huang, Juan Song () and Wubin Bai ()
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Yihang Wang: University of North Carolina at Chapel Hill
Zeka Chen: University of North Carolina at Chapel Hill
Brayden Davis: UNC/NCSU Joint Department of Biomedical Engineering
Will Lipman: University of North Carolina at chapel Hill
Sicheng Xing: UNC/NCSU Joint Department of Biomedical Engineering
Lin Zhang: University of North Carolina at Chapel Hill
Tian Wang: UNC/NCSU Joint Department of Biomedical Engineering
Priyash Hafiz: UNC/NCSU Joint Department of Biomedical Engineering
Wanrong Xie: University of North Carolina at Chapel Hill
Zijie Yan: University of North Carolina at Chapel Hill
Zhili Huang: Fudan University
Juan Song: University of North Carolina at Chapel Hill
Wubin Bai: University of North Carolina at Chapel Hill

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Transdermal drug delivery is of vital importance for medical treatments. However, user adherence to long-term repetitive drug delivery poses a grand challenge. Furthermore, the dynamic and unpredictable disease progression demands a pharmaceutical treatment that can be actively controlled in real-time to ensure medical precision and personalization. Here, we report a spatiotemporal on-demand patch (SOP) that integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. Precise control of drug release to targeted locations (

Date: 2024
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DOI: 10.1038/s41467-023-44532-0

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