Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

Dicky Pranantyo, Chun Kiat Yeo, Yang Wu, Chen Fan, Xiaofei Xu, Yun Sheng Yip, Marcus Ivan Gerard Vos, Surendra H. Mahadevegowda, Priscilla Lay Keng Lim, Liang Yang, Paula T. Hammond, David Ian Leavesley, Nguan Soon Tan () and Mary B. Chan-Park ()
Additional contact information
Dicky Pranantyo: Nanyang Technological University
Chun Kiat Yeo: Nanyang Technological University
Yang Wu: Nanyang Technological University
Chen Fan: Agency for Science, Technology and Research (A*STAR)
Xiaofei Xu: Nanyang Technological University
Yun Sheng Yip: Nanyang Technological University
Marcus Ivan Gerard Vos: Nanyang Technological University
Surendra H. Mahadevegowda: Nanyang Technological University
Priscilla Lay Keng Lim: Agency for Science, Technology and Research (A*STAR)
Liang Yang: Southern University of Science and Technology
Paula T. Hammond: Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology
David Ian Leavesley: Agency for Science, Technology and Research (A*STAR)
Nguan Soon Tan: Nanyang Technological University
Mary B. Chan-Park: Nanyang Technological University

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a dual-functionality hydrogel dressing with intrinsic antibiofilm and antioxidative properties that are synergistic and low-leaching. The hydrogel is a crosslinked network with tethered antibacterial cationic polyimidazolium and antioxidative N-acetylcysteine. In a murine diabetic wound model, the hydrogel accelerates the closure of wounds infected with methicillin-resistant Staphylococcus aureus or carbapenem-resistant Pseudomonas aeruginosa biofilm. Furthermore, a three-dimensional ex vivo human skin equivalent model shows that N-acetylcysteine promotes the keratinocyte differentiation and accelerates the re-epithelialization process. Our hydrogel dressing can be made into different formats for the healing of both flat and deep infected chronic wounds without contamination of the wound or needing other modalities such as photothermal irradiation.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-44968-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44968-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-44968-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().