Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G. Catanzaro, Antonino Catanzaro, Timothy Rodwell, Judy S. B. Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D. DeSilva, Bjoern Peters, Alessandro Sette and Cecilia S. Lindestam Arlehamn ()
Additional contact information
Sudhasini Panda: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Jeffrey Morgan: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Catherine Cheng: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Mayuko Saito: Tohoku University Graduate School of Medicine
Robert H. Gilman: Johns Hopkins School of Public Health
Nelly Ciobanu: Phthisiopneumology Institute
Valeriu Crudu: Phthisiopneumology Institute
Donald G. Catanzaro: University of Arkansas
Antonino Catanzaro: University of California San Diego
Timothy Rodwell: University of California San Diego
Judy S. B. Perera: General Sir John Kotelawala Defense University
Teshan Chathuranga: General Sir John Kotelawala Defense University
Bandu Gunasena: National Hospital for Respiratory Diseases
Aruna D. DeSilva: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Bjoern Peters: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Alessandro Sette: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Cecilia S. Lindestam Arlehamn: Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-treatment for active tuberculosis (ATB) reveals IFNγ-specific T cell responses against 137 unique epitopes. Of these, 16% are recognized by two or more participants and predominantly derived from cell wall and cell processes antigens. There is differential recognition of antigens, including TB vaccine candidate antigens, between ATB participants and interferon-gamma release assay (IGRA + /−) individuals. We developed an ATB-specific peptide pool (ATB116) consisting of epitopes exclusively recognized by ATB participants. This pool can distinguish patients with pulmonary ATB from IGRA + /− individuals from various geographical locations, with a sensitivity of over 60% and a specificity exceeding 80%. This proteome-wide screen of T cell reactivity identified infection stage-specific epitopes and antigens for potential use in diagnostics and measuring Mtb-specific immune responses.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-45058-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45058-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-45058-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().