Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating

Yang Zhu (), Kaicheng Deng, Jianwei Zhou, Chong Lai, Zuwei Ma, Hua Zhang, Jiazhen Pan, Liyin Shen, Matthew D. Bucknor, Eugene Ozhinsky, Seungil Kim, Guangjie Chen, Sang-ho Ye, Yue Zhang, Donghong Liu, Changyou Gao, Yonghua Xu (), Huanan Wang () and William R. Wagner ()
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Yang Zhu: Zhejiang University
Kaicheng Deng: Zhejiang University
Jianwei Zhou: NingboTech University
Chong Lai: Zhejiang University
Zuwei Ma: University of Pittsburgh
Hua Zhang: Zhejiang University
Jiazhen Pan: Zhejiang University
Liyin Shen: Zhejiang University
Matthew D. Bucknor: University of California
Eugene Ozhinsky: University of California
Seungil Kim: University of Pittsburgh
Guangjie Chen: Zhejiang University
Sang-ho Ye: University of Pittsburgh
Yue Zhang: University of California
Donghong Liu: Zhejiang University
Changyou Gao: Zhejiang University
Yonghua Xu: Department of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Shanghai Xuhui Central Hospital
Huanan Wang: Zhejiang University
William R. Wagner: University of Pittsburgh

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.

Date: 2024
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DOI: 10.1038/s41467-024-45437-2

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