Characterisation of colistin resistance in Gram-negative microbiota of pregnant women and neonates in Nigeria

E. A. R. Portal (), K. Sands (), C. Farley, I. Boostrom, E. Jones, M. Barrell, M. J. Carvalho, R. Milton, K. Iregbu, F. Modibbo, S. Uwaezuoke, C. Akpulu, L. Audu, C. Edwin, A. H. Yusuf, A. Adeleye, A. S. Mukkadas, D. Maduekwe, S. Gambo, J. Sani, T. R. Walsh and O. B. Spiller
Additional contact information
E. A. R. Portal: Cardiff University
K. Sands: Cardiff University
C. Farley: Cardiff University
I. Boostrom: Cardiff University
E. Jones: Cardiff University
M. Barrell: Cardiff University
M. J. Carvalho: Cardiff University
R. Milton: Cardiff University
K. Iregbu: National Hospital Abuja
F. Modibbo: Murtala Muhammad Specialist Hospital
S. Uwaezuoke: Federal Medical Centre –Jabi
C. Akpulu: University of Oxford
L. Audu: National Hospital Abuja
C. Edwin: Department of Medical Microbiology Aminu Kano Teaching Hospital
A. H. Yusuf: Department of Medical Microbiology Aminu Kano Teaching Hospital
A. Adeleye: Department of Medical Microbiology Aminu Kano Teaching Hospital
A. S. Mukkadas: Department of Medical Microbiology Aminu Kano Teaching Hospital
D. Maduekwe: Wuse General Hospital Abuja
S. Gambo: Murtala Muhammed Specialist Hospital
J. Sani: Department of Paediatrics Abdullahi Wase Teaching Hospital
T. R. Walsh: Cardiff University
O. B. Spiller: Cardiff University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract A mobile colistin resistance gene mcr was first reported in 2016 in China and has since been found with increasing prevalence across South-East Asia. Here we survey the presence of mcr genes in 4907 rectal swabs from mothers and neonates from three hospital sites across Nigeria; a country with limited availability or history of colistin use clinically. Forty mother and seven neonatal swabs carried mcr genes in a range of bacterial species: 46 Enterobacter spp. and single isolates of; Shigella, E. coli and Klebsiella quasipneumoniae. Ninety percent of the genes were mcr-10 (n = 45) we also found mcr-1 (n = 3) and mcr-9 (n = 1). While the prevalence during this collection (2015-2016) was low, the widespread diversity of mcr-gene type and range of bacterial species in this sentinel population sampling is concerning. It suggests that agricultural colistin use was likely encouraging sustainment of mcr-positive isolates in the community and implementation of medical colistin use will rapidly select and expand resistant isolates.

Date: 2024
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DOI: 10.1038/s41467-024-45673-6

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