Experimental evidence for cancer resistance in a bat species

Rong Hua, Yuan-Shuo Ma, Lu Yang, Jun-Jun Hao, Qin-Yang Hua, Lu-Ye Shi, Xiao-Qing Yao, Hao-Yu Zhi and Zhen Liu ()
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Rong Hua: Chinese Academy of Sciences
Yuan-Shuo Ma: Chinese Academy of Sciences
Lu Yang: Chinese Academy of Sciences
Jun-Jun Hao: Chinese Academy of Sciences
Qin-Yang Hua: Chinese Academy of Sciences
Lu-Ye Shi: Chinese Academy of Sciences
Xiao-Qing Yao: Chinese Academy of Sciences
Hao-Yu Zhi: Chinese Academy of Sciences
Zhen Liu: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be systematically examined. Here, we investigate cancer resistance across seven bat species by activating oncogenic genes in their primary cells. Both in vitro and in vivo experiments suggest that Myotis pilosus (MPI) is particularly resistant to cancer. The transcriptomic and functional analyses reveal that the downregulation of three genes (HIF1A, COPS5, and RPS3) largely contributes to cancer resistance in MPI. Further, we identify the loss of a potential enhancer containing the HIF1A binding site upstream of COPS5 in MPI, resulting in the downregulation of COPS5. These findings not only provide direct experimental evidence for cancer resistance in a bat species but also offer insights into the natural mechanisms of cancer resistance in mammals.

Date: 2024
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DOI: 10.1038/s41467-024-45767-1

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